Protein Modification Reagents
Medchemexpress LLC DBCO-Cy3 | 1782950-79-1 | MFCD28505574 | 95.1% | 983.18 | C50H54N4O11S3 | 10 MG
DBCO-Cy3 is a DBCO-functionalized Cy3 fluorescent dye designed for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) labeling of azide-containing biomolecules. It couples a dibenzocyclooctyne reactive group to an orange Cy3 fluorophore (excitation ~555 nm, emission ~580 nm), and is supplied with supporting documentation for analytical and safety data.
- Enables copper-free SPAAC labeling of azide-containing biomolecules.
- Orange fluorescence with excitation ~555 nm and emission ~580 nm.
- Supplied as a 10 MG dry powder, soluble in DMSO.
- High purity suitable for imaging applications.
- Includes datasheet, COA, and SDS for quality and safety information.
Medchemexpress LLC Benzyl-PEG5-Ots 500mg
Benzyl-PEG5-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs
Medchemexpress LLC Benzyl-PEG4-Ots 500mg
Benzyl-PEG4-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs
Medchemexpress LLC Mal-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-52-8 | 1559.62 | C74H98N10O27 | 10 MG
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a cleavable antibody-drug conjugate (ADC) drug-linker conjugate that combines a Mal-PEG4-VC-PAB cleavable linker with the cytotoxic payload DMEA-PNU-159682 for use in ADC research and drug-conjugate development.
- Cleavable ADC drug-linker conjugate suitable for antibody-drug conjugate synthesis.
- Contains a maleimide functional group for thiol conjugation.
- High molecular weight for payload delivery and characterization.
- Supplied in small research pack sizes for controlled studies.
- Store solid at -20°C, protect from light, and keep under inert gas; follow solvent storage recommendations for solutions.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]- | 663921-15-1 | MFCD11041129 | 99.9% | 265.30 g/mol | C11H23NO6 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202942.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]- | 663921-15-1 | MFCD11041129 | 99.9% | 265.30 g/mol | C11H23NO6 | 100 MG
NH2-PEG4-CH2CH2COOH is a cleavable four-unit polyethylene glycol (PEG) linker with an N-terminal amine and a terminal propanoic acid, designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis.
- Cleavable 4-unit PEG linker.
- Amine functional group for conjugation.
- Terminal carboxylic acid for coupling reactions.
- High purity (99.9%).
- Molecular weight 265.30 g/mol.
- Soluble in DMSO.
- Available as a 100 MG pack.
Medchemexpress LLC Dbco-PEG4-Val-Cit-PAB-MMAE | 2129164-91-4 | 99.2% | 1658.03 g/mol | C88H128N12O19 | 5 MG
DBCO-PEG4-Val-Cit-PAB-MMAE is a cleavable drug-linker conjugate that combines a DBCO-functionalized PEG4-Val-Cit-PAB linker with the cytotoxic payload MMAE. It is supplied as a white to off-white solid for use as a click-chemistry reagent and building block in antibody-drug conjugate synthesis; solutions are unstable and should be prepared fresh.
- Suitable for strain-promoted alkyne-azide cycloaddition (SPAAC)
- Val-Cit-PAB motif provides a cathepsin-cleavable linker
- MMAE payload acts as a tubulin polymerization inhibitor
- High purity supplied (99.18%)
- Provided as a solid; store powder at -20°C
Cayman Chemical BIOnT PROTAC FRGmnt lbrar 10mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
![eMolecules 2100306-50-9 | N-(Azido-PEG3)-N-Fluorescein-PEG3-acid | Broadpharm | MFCD30723236 | 811.860 | C38H45N5O13S | 98.000 | OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])C(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12 | 5mg | 343283699](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203407.JPG-250.jpg)
eMolecules 2100306-50-9 | N-(Azido-PEG3)-N-Fluorescein-PEG3-acid | Broadpharm | MFCD30723236 | 811.860 | C38H45N5O13S | 98.000 | OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])C(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12 | 5mg | 343283699
N-(Azido-PEG3)-N-Fluorescein-PEG3-acid | Broadpharm | 2100306-50-9 | MFCD30723236 | 811.860 | C38H45N5O13S | 98.000 | OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])C(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12 | 5mg | 343283699
Medchemexpress LLC NH2-C5-PEG4-N3-L-lysine-PEG3-N3 | 99.4% | 619.71 g/mol | C25H49N9O9 | 1 MG
NH2-C5-PEG4-N3-L-lysine-PEG3-N3 is a cleavable 7-unit polyethylene glycol (PEG) linker bearing an azide functionality for use in click chemistry and antibody-drug conjugate (ADC) synthesis. It enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) bioconjugation workflows, and is supplied as a highly pure, water-soluble reagent.
- Cleavable 7-unit PEG linker
- Contains an azide group for click chemistry
- Suitable for CuAAC and SPAAC bioconjugation
- Soluble in water at ≥ 100 mg/mL
- High purity: 99.42%
- Available in small-scale quantities for research use
Medchemexpress LLC WDR5 degrader-1 | 3032434-45-7 | 98.00% | 972.98 | 5 MG
WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. It selectively degrades WDR5 over the CRBN neo-substrate IKZF1.
- Cereblon (CRBN)-recruiting degrader
- Selectively degrades WDR5 over IKZF1
Medchemexpress LLC PROTAC EGFR degrader 3 | 2768472-28-0 | 97.4% | C60H77N13O5S | 1 MG
PROTAC EGFR degrader 3 is a potent PROTAC EGFR degrader. It exhibits excellent cellular activity against H1975 and HCC827 cells with high selectivity. Research indicates that the lysosome is involved in the degradation process of EGFR mutant degradation. This product is intended for research use only and not for sale to patients.
- Potent PROTAC EGFR degrader
- Excellent cellular activity against H1975 and HCC827 cells
- High selectivity
- Lysosome involved in EGFR mutant degradation process
- For research use only
Medchemexpress LLC 3031336-58-7 | 95.6% | 1151.78 | C58H72ClFN12O8S | 5 MG
PROTAC EGFR degrader 2 is a PROTAC designed to selectively degrade the epidermal growth factor receptor (EGFR) and to support biochemical and cellular research into EGFR-driven signaling and antiproliferative effects.
- Potent EGFR degrader with reported DC50 36.51 nM.
- Exhibits antiproliferative activity (IC50 ≈4.0 nM).
- Purity 95.6% suitable for research applications.
- DMSO solubility up to 100 mg/mL; ultrasonic assistance recommended.
- Supplied as a light yellow to yellow solid for handling convenience.
- Store solid at 4°C protected from light; in solution store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Pomalidomide-PEG6-NH2 (hydrochloride) | 2341841-01-6 | 98.01% | 574.02 | 25 MG
Pomalidomide-PEG6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a 6-unit PEG linker, used in PROTAC technology.
- Incorporates pomalidomide-based cereblon ligand
- Features 6-unit PEG linker
- Used in PROTAC technology
- Targets cereblon
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins